pentobarbital will reduce the extent or impact of nilotinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will reduce the level or outcome of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Strong CYP3A4 inducers may well lessen midostaurin con